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Mysoline in Epilepsy: A Comparison with Older Methods of Treatment

Ballamona Hospital, Isle of Man

ABSTRACT

A small group of epileptics have been treated with mysoline. Major epileptic activity was increased in eight cases out of nine. One case was rendered free from fits although his E.E.G. did not improve. There was slight improvement in one-third of cases with minor epilepsy. E.E.G.s were unimproved after mysoline. Mysoline is therapeutically less effective than phenobarbitone or soluble phenytoin.

In this series two cases developed status epilepticus during orthodox drug transition. One status proved fatal. Toxic symptoms, in particular significant falls in the total white blood counts, occurred in more than half the patients and necessitated an uneconomical degree of clinical examination and pathological investigation certainly greater than that required during treatment with established anticonvulsants.

Received for publication June 6, 1953.