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Journal of Mental Science (1954) 100: 536-542. doi: 10.1192/bjp.100.419.536
© 1954 The Royal College of Psychiatrists
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Variations in the Blood Levels of Acetoin and Butane-2:3-Diol in Normal Individuals and Mental Patients

J. Dawson, M.Sc., M.B., Ch.B., and R. P. Hullin, Ph.D., M.Sc., A.R.I.C., Lecturers

Department of Biochemistry, University of Leeds

Arthur Pool, M.B., Ch.B., M.R.C.P., D.P.M., Consultant Psychiatrist, Oldham and Rochdale Hospital Group, Lately Physician Superintendent, The Retreat, York

ABSTRACT

  1. In the non-fasting state the blood acetoin (AMC) level of a group of mental patients in the manic and depressed phases was higher than that of a normal group or of a group of psychoneurotic individuals: the degree of variation in blood level was also greater in the psychotic group.
  2. In normal individuals, the blood AMC level in the fasting state is raised and the butane-2:3-diol (2:3BG) level reduced as compared with the levels in the non-fasting state.
  3. In the fasting state, manic-depressive psychosis is characterized by an increased total concentration of AMC and 2:3BG in the blood. In the depressed phases of the psychosis, the carbinol level is raised but no significant change in the glycol concentration occurs. In the manic phases, the blood carbinol level is reduced whilst the glycol level is greater than normal. These variations produce a marked change in the 2:3BG-AMC ratio in the manic phase.

Received for publication October 9, 1953.




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Copyright © 1954 The Royal College of Psychiatrists.