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Psychiatric Uses of Meratran

Herrison Hospital, Dorchester

ABSTRACT

The author describes a controlled clinical trial with a new anti-depressant on forty chronic psychotic patients. Beneficial effects were observed in those cases which exhibited depressive features without anxiety or a tendency to agitation. Patients suffering from delusional systems or hallucinations are not likely to improve. Whilst electro-convulsive therapy is the treatment of choice in acute endogenous depressive states Meratran may be found (a) to give relief of symptoms in chronically depressed patients where the depression is reactive in type, or secondary to senile change; or (b) to combat the lethargy induced by chlorpromazine or the depression following prolonged reserpine therapy. The results of this preliminary investigation would seem to justify further work along these lines.