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Toxic Psychosis under Cortisone and Corticotrophin

St. Augustine's Hospital, Chartham Down, Canterbury

ABSTRACT

1. Psychotic reactions may be induced by Cortisone or by A.C.T.H., in the course of which suicidal depression or serious mental disturbance requiring leucotomy may add to the known physical risks of treatment with these hormones.
   
2. No constant feature of premorbid personality has been determined that may guide clinically in the anticipation of the more serious grades of mental reaction.
   
3. Women of menopausal age appear to be more susceptible to these reactions.
   
4. There is no correlation between electrolyte imbalance and the development of mental reactions.