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Assessing a New Phenothiazine

Banstead Hospital, Sutton, Surrey

ABSTRACT

Twenty-eight female deteriorated schizophrenic patients who had relapsed following chlorpromazine therapy were given further treatment with either chlorpromazine or 7044 R.P. Behaviour was assessed with the aid of the authors' Behaviour Rating Scale and no statistically acceptable evidence in favour of one or other of these two compounds in terms of this scale emerged. It was found, however, that slightly smaller doses of 7044 R.P. than chlorpromazine were required, and that one of the patients receiving 7044 R.P. developed leucopenia and another a skin rash.

No drug is likely to replace chlorpromazine unless it is more effective, safer or cheaper. 7044 does not appear to have any of these advantages in the case of deteriorated schizophrenic patients.