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A Clinical Trial of Stemetil (Prochlorperazine)

Pastures Hospital, Mickleover, Derby

Fritz Berliner, M.D., Consultant Psychiatrist

Pastures Hospital, Mickleover, Derby

ABSTRACT

A new therapeutic agent prochlorperazine ("Stemetil") was administered to 50 chronic male schizophrenics. The results were most encouraging, especially in the group of simple and hebephrenic schizophrenics. Affect and drive returned in the majority of those patients in whom chlorpromazine had failed. The drug is active in lower dosage than chlorpromazine, as was noted by Broussolle and Dubor (1956). Although drowsiness was not infrequently present early in the treatment it did not persist, and the patients were much more alert than chlorpromazine-treated patients. Serious side-effects were absent with the exception of the rather alarming extrapyramidal syndrome mentioned above. However, if the drug is introduced in small dosage, e.g. 10 mg. t.i.d., and gradually increased to the optimum, these side-effects are minimal and respond rapidly when prochlorperazine is combined with Phenergan 25 mg. t.i.d.