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The Clinical Differentiation of Pick's Disease

Royal Edinburgh Hospital for Mental and Nervous Disorders

Anne le Roux, B.Sc., M.B., Ch.B., Lecturer in Pathology

Edinburgh University

James H. Brown, M.B., M.R.C.P.E., D.P.M., Senior Registrar

Dundee Royal Mental Hospital

ABSTRACT

Three cases of Pick's disease, confirmed atautopsy, are reported.

A hypothesis regarding the differentiation of this condition from other pre-senile dementias on clinical grounds alone was made during the study of the first case; and this hypothesis was tested and verified when the other two cases were encountered.

The clinical features are discussed, and special reference is made to a generalized hyperalgesia displayed by all three patients.