BJP CPD Online e-learning site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

Journal of Mental Science (1958) 104: 1056-1061. doi: 10.1192/bjp.104.437.1056
© 1958 The Royal College of Psychiatrists
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hargreaves, G. R.
Right arrow Articles by Roberts, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hargreaves, G. R.
Right arrow Articles by Roberts, J. M.

Treatment of Anxiety States

II.—Clinical Trial of Benactyzine in Anxiety States

G. R. Hargreaves, O.B.E., M.Sc., M.R.C.S., Nuffield Professor of Psychiatry

Max Hamilton, M.D., D.P.M., Senior Research Fellow

Julian M. Roberts, M.B., Ch.B., D.P.M., Lecturer

Leeds University Department of Psychiatry, the General Infirmary at Leeds

ABSTRACT

  1. A clinical trial of benactyzine in anxiety states is described. All patients received simple psychotherapy, and in addition 14 received benactyzine and 12 were given blank tablets.
  2. The patient's condition at the start and end of the trial was measured with a rating scale with items dealing with specific symptoms. Although greater improvement occurred in the patients given drug compared with those given placebo in 11 out of 13 items, in only one did it reach a level of statistical significance.
  3. The use of two raters at the same interview provided evidence that knowledge of side effects did not influence ratings.
  4. The amount of improvement is not related to the length of illness, the previous personality, the presence of precipitating factors or family history of mental illness.
  5. The analysis of results was made complicated by a high correlation between original scores and amount of improvement, and by the use of three pairs of raters in the trial. This was dealt with by analysis of covariance.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1958 The Royal College of Psychiatrists.