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Journal of Mental Science (1958) 104: 1136-1148. doi: 10.1192/bjp.104.437.1136
© 1958 The Royal College of Psychiatrists
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Measurements of Effects of Hyaluronidase in Insulin Coma Treatment

K. E. Schmidt, M.D., M.R.C.S., L.R.C.P., D.P.M., Assistant Psychiatrist

Hill End Hospital, St. Albans, Herts

J. Tong, Senior Clinical Psychologist

Rampton Hospital, Retford, Notts

ABSTRACT

A trial has been carried out on 32 schizophrenic patients receiving courses of insulin coma treatment to determine by measurements, whether the various stages of the coma could be favourably influenced by the addition of hyaluronidase to the insulin dosage. The patients were divided into four groups of 8 patients each, who received the hyaluronidase (apart from a pilot-group) on alternate days, alternate weeks, and from the 16th to the 30th coma respectively.

The factors assessed were duration of sopor, onset of coma, stability of onset of coma, waking duration, necessity for intravenous glucose interruption, epileptiform fits, after-shocks and insulin dosage. Most of the factors appeared significantly favourably influenced by the addition of hyaluronidase in a few patients only, except for dosage where no drastic reduction appeared to be indicated or possible in any single case with the criteria adopted.

An attempt is made to correlate these data with characteristics of the patients and the features of their psychosis. The results indicate the possible importance ofthe acute hebephrenic group.






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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1958 The Royal College of Psychiatrists.