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Body Fluid Indoles of Normal and Mentally-Ill Subjects

I. Preliminary Survey of the Occurrence of Some Urinary Indoles

Department of Biochemistry, Institute of Psychiatry, Maudsley Hospital, S.E.5

ABSTRACT

1. Urinary indole excretion was studied by two-dimensional paper chromatography in 63 normal subjects, 65 schizophrenics, 60 cases of miscellaneous mental illness, 31 new admissions to a psychiatric observation ward and 35 cases of physical illness from a general hospital.
   
2. The three groups of mentally-ill subjects showed a higher total of indole spots on their urine chromatograms than did the other two groups. The increases were most marked in two unknown indoles, and they occurred most frequently in acutely ill patients.
   
3. No evidence was obtained for an abnormal indole excretion greater than about 10 mg./24 hours in mentally ill subjects.