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Journal of Mental Science (1958) 104: 1219-1225. doi: 10.1192/bjp.104.437.1219
© 1958 The Royal College of Psychiatrists
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A Controlled Investigation of the Effects of Cyclizine Hydrochloride in Chronic Psychosis

B. G. Fleming, L.R.C.P.&S.I., D.P.M., Research Medical Officer and J. D. C. Currie, M.B., B.S., D.P.M., Senior Medical Officer

Powick Hospital, near Worcester

ABSTRACT

A "blind" controlled trial of cyclizine in the short-term treatment of chronic psychosis was carried out. The object was to determine whether cyclizine is a potential tranquilizer. Thirty chronic disturbed schizophrenics received cycizine and a placebo alternately. The design enabled group comparisons to be made between the effects of the two preparations, and also afforded direct comparisons between the responses of each individual patient to both preparations administered consecutively. The criteria of therapeutic response were based upon rating scale scores, clinical assessments,and the recording of abnormal behaviour incidents. A simple statistical analysis failed to reveal a "significant" difference between the treatment effectsof cyclizineand placebo in terms of the observations made on the 30 patients included in the trial. From this it was deduced that cyclizine is not a specific tranquilizer. However, a considerable improvement rate was recorded for both preparations, and the possible implications of this fact were emphasized in relation to the extravagant claims so frequently made for tranquilizers in general.






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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1958 The Royal College of Psychiatrists.