Journal of Mental Science (1960) 106: 1455-1458. doi: 10.1192/bjp.106.445.1455
© 1960 The Royal College of Psychiatrists
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Ethinamate and Methyprylone as Hypnotics: A Comparative Trial

I. C. Lodge Patch, M.D., M.R.C.P., D.P.M., Senior Registrar, M. D. Eilenberg, M.B., M.R.C.P., D.P.M., Senior Registrar and E. H. Hare, M.D., D.P.M., Physician, Bethlem Royal and The Maudsley Hospitals

ABSTRACT

  1. By a controlled clinical trial, the hypnotic efficacy of ethinamate ("Valmidate") and methyprylone ("Noludar") were compared with each other and with butobarbitone and a placebo. The subjects were 40 psychiatric patients and an average of 24 nights sleep per patient was objectively recorded.
  2. The trial was divided between two hospitals, with consistent results.
  3. Butobarbitone 200 mg. was significantly more effective than the other drugs on most of the criteria used, and this comparative efficacy was uninfluenced by factors of age, sex or diagnosis.
  4. Methyprylone 200 mg. was more effective than the placebo, but did not differ significantly from ethinamate 500 mg. Ethinamate 500 mg. was not significantly more effective than the placebo.