HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dewhurst, W. G. Articles by Pare, C. M. B. Search for Related Content PubMed PubMed Citation Articles by Dewhurst, W. G. Articles by Pare, C. M. B.

A Clinical and Biochemical Study of Monoamine Oxidase Inhibition in Depressed Patients

I. A Clinical Trial of Nialamide

Bethlem Royal and The Maudsley Hospitals

ABSTRACT

A controlled double-blind trial of Nialamide has been carried out in 28 depressed subjects. Seven patients showed improvement and in 4 of these the improvement was attributed to the drug. In these 4 patients environmental precipitating factors were inconspicuous.

In the dosage used, no clinical toxic effects were observed and only one patient showed any significant rise in transaminase levels. In this respect the drug appears to be appreciably safer than iproniazid in its short term toxic effects.