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A Comparative Trial of Four Mono-Amine Oxidase Inhibitors on Chronic Depressives

Saxondale Hospital, Nottingham

ABSTRACT

A comparative trial of four mono-amine oxidase inhibitors on chronic depressives resistant to other forms of treatment is described. The 50–60 age group showed the best response to treatment. The only symptom associated with success of treatment at a statistically significant level was "accentuation of symptoms in the morning". Nardil was the beneficial drug, particularly in the over 50 age group; Niamid most effective for patients under 40 and Cavodil in the dosage used was inferior to the other drugs. The commonest major side-effect was hypomania. A case of jaundice and one of toxic confusion is also described. It is considered that the mono-amine oxidase inhibitors are of definite therapeutic value in the treatment of depression especially in chronic depressives resistant to other forms of treatment.