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A Clinical Trial of Imipramine ("Tofranil") on Depressed Patients

University of Illinois, Urbana, Illinois, U.S.A.

G. H. Collins, M.D., D.P.M., Consultant Psychiatrist

Kingsway Hospital, Derby

^* Formerly Medical Director, Burden Neurological Institute, Bristol.

Formerly Deputy Medical Superintendent, Barnwood House, Gloucester.

ABSTRACT

Fifteen depressed patients were given a nine-weeks course of Tofranil, on a double-blind system with a similar course on facsimile placebo tablets. Some were given the placebo course first and some the Tofranil.

Survey of the results suggests that the drug had some effect in making the patients more settled. The effect, however, could not be shown significantly on a planned marking scale.

Mention is also made of the side-effects which were encountered.