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Controlled Clinical Trial of Isocarboxazid ("Marplan")in Hospital Psychiatry

St. Francis Hospital, Haywards Heath, Sussex

^* Present address: 153C Matunga, Bombay 19, India.

ABSTRACT

In a strictly controlled trial, isocarboxazid (Marplan) appears to be a useful drug for the treatment of depressions in general.

Secondary depressions in elderly patients in whom features of agitation are marked, respond extremely well.

Psychoneurotic depressions superimposed on an obsessional compulsive neurosis, and depressions with anxiety, all of a younger age group, and probably in females with an asthenic or dysplastic diathesis, may be helped also.

Classic endogenous depression of considerable severity and recurrent depressions of a similar nature are not helped by Marplan.

Minor side-effects clinically resembling those of reserpine but less frequent, appear at the commencement of treatment, and eventually lessen, unlike those produced by reserpine. In a case of active pulmonary tuberculosis, isocarboxazid was successfully used in combination with P.A.S.