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Adjunctive Therapy in Depression: A Controlled Trial of Nialamide

The Royal Edinburgh Hospital, Morningside

F. M. Martin, B.A., Ph.D.

Department of Social Medicine, University of Edinburgh

ABSTRACT

1. A controlled trial of nialamide compared with chlorpromazine is reported in 50 hospitalized depressive patients.
   
2. At two weeks the improvement rate was 76·9 per cent. for nialamide and 66·6 per cent. for chlorpromazine. The final improvement rates (i.e. at the completion of the trial) were 50 per cent. for nialamide and 42 per cent. for chlorpromazine. Neither the short-term nor the longer-term difference between treatment groups was statistically significant.
   
3. These results are discussed in relation to spontaneous recovery and the therapeutic effect of hospitalization.