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The British Journal of Psychiatry (1963) 109: 395-398. doi: 10.1192/bjp.109.460.395
© 1963 The Royal College of Psychiatrists
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Fluid Distribution and the Response of Depression to E.C.T. and Imipramine

D. G. BROWN M.B., M.R.C.P.E., D.P.M.1, R. P. HULLIN Ph.D., M.Sc., F.R.I.C.2, and J. M. ROBERTS M.D., D.P.M.3

1 Lecturer in Psychiatry, University Department of Psychiatry, 15 Hyde Terrace, Leeds 2
2 Lecturer in Biochemistry, University Department of Biochemistry, 9 Hyde Terrace, Leeds 2
3 Part-time Lecturer in Psychiatry; Consultant Psychiatrist, St. James's Hospital, Leeds 9

The effect of E.C.T. and of imipramine on the extracellular fluid volume of twenty-eight patients suffering from primary depressive disorders was studied by means of a modified thiocyanate method and a clinical rating scale. All the patients improved; in twenty-two the E.C.F. increased and in six it fell. There was an overall correlation between decrease in symptom score and increase in E.C.F. that was significant at the .05 level, but not when the two series (E.C.T. 18, imipramine 10) were taken separately. Twenty patients gained weight, but amounts were small, and the correlation with symptom score was non-significant. The findings were discussed in relation to previous work on sodium metabolism and water balance in depressive disorders, and were thought to support the idea of a shift of fluid from intracellular to extracellular spaces that underlies response to imipramine as well as E.C.T. The demonstration of a divergent subgroup might be of nosological significance.




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Copyright © 1963 The Royal College of Psychiatrists.