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The British Journal of Psychiatry (1963) 109: 428-432. doi: 10.1192/bjp.109.460.428
© 1963 The Royal College of Psychiatrists
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A Trial of Fluphenazine in Schizophrenia

JOHN MILLAR M.B., Ch.B., D.P.M.1

1 Carlton Hayes Hospital, Narborough, near Leicester

Thirty-eight chronic female schizophrenics who had been treated with chlorpromazine, and usually with electro-convulsant therapy, insulin coma therapy, leucotomy or a combination of these three procedures, participated in a trial which was designed in three phases:

(i) Fluphenazine was substituted for chlorpromazine and resulted in statistically significant improvement.

(ii) The patients were divided at random into two groups and given fluphenazine or placebo tablets under double-blind conditions.

(iii) The fluphenazine and placebo groups were crossed over. It was apparent that chlorpromazine was more effective than placebo and that fluphenazine produced greater improvement than did chlorpromazine.






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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1963 The Royal College of Psychiatrists.