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The British Journal of Psychiatry (1965) 111: 134-141. doi: 10.1192/bjp.111.471.134
© 1965 The Royal College of Psychiatrists
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Drug Treatment of Anxiety: A Controlled Study of Opipramol and Chlordiazepoxide

H. H. GROSSER M.D.1 and E. RYAN M.B., D.P.M.2

1 Senior Registrar, Uffculme Clinic, Birmingham 13; Research Assistant, NeuroPsychiatric University Clinic, Ortenbergstrasse 8, 355 Marburg/Lahn, Germany
2 Registrar, Uffculme Clinic, Birmingham 13; St. Finan's Hospital, Killarney, Co. Kerry, Ireland

This paper reports a double-blind cross-over trial comparing the efficacy of opipramol and chlordiazepoxide in the treatment of patients suffering from non-psychotic psychiatric conditions characterized or significantly accompanied by anxiety features.

The results are evaluated in two different ways. Actual change (improvement and deterioration) as recorded is expressed as percentage of possible change. Secondly, changes are calculated in terms of absolute and relative differences of means.

Both methods of evaluation suggest that, in the dosages used, both drugs are of equal efficacy in the treatment of the described conditions.






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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1965 The Royal College of Psychiatrists.