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The British Journal of Psychiatry (1965) 111: 511-516. doi: 10.1192/bjp.111.475.511
© 1965 The Royal College of Psychiatrists
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The Management of Depression in Hospital

A Comparative Trial of Desipramine and Imipramine

JOHN WALDRON M.B., D.P.M.1 and T. J. N. BATES M.A., M.D., D.P.M.2

1 Senior Assistant Psychiatrist, Saxondale Hospital, Radcliffe-on-Trent, Nottinghamshire
2 Consultant Psychiatrist, Mapperly Hospital, Nottingham

This study consists of a double-blind trial of desipramine against an established anti-depressant drug, imipramine. It also attempts to devise a rationale for the treatment of hospitalized depressives with these drugs.

The results of the controlled trial show that there is little difference between the two drugs as regards their anti-depressant activity or speed of action. Side-effects also tended to be similar in frequency of occurrence and nature.

Certain items in the clinical presentation have been shown to be correlated with outcome and scoring on the Hamilton scale has been shown to be a particularly useful guide to further management at the end of one week of therapy.

Submitted on July 6, 1964






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1965 The Royal College of Psychiatrists.