Mood, Motility and 17-Hydroxycorticoid Excretion
A Polyvariable Case Study
MELVIN SCHWARTZ M.D.,
ARNOLD J. MANDELL M.D.1,
RICHARD GREEN B.A.2, and
RICHARD FERMAN M.D.3
1 Residents in Psychiatry, Neuropsychiatric Institute
2 Senior Medical Student, U.C.L.A. Medical Center
3 Director Biochemical Correlates Laboratory, Assistant Professor, Department of Psychiatry, U.C.L.A. Medical Center, Los Angeles 24, California
A repeated measurement, polyvariable study of a manic-depressive patient throughout one cycle has: (1) added evidence in favour of the previously reported relationship between depression and increased urinary excretion of 17-hydroxycorticoids, with, however, the introduction of the possibility that it is not as specific as previously reported in that the manic state is also associated with periodic elevations in corticoid excretion; (2) suggested the possibility that non-specific "discomfort" and motility parameters warrant attention and control in such studies.
Submitted on March 4, 1965
