BJP RCPsych Publications
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

The British Journal of Psychiatry (1966) 112: 167-171. doi: 10.1192/bjp.112.483.167
© 1966 The Royal College of Psychiatrists
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by INGRAM, C. G.
Right arrow Articles by BROVINS, W. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by INGRAM, C. G.
Right arrow Articles by BROVINS, W. G.

The Reproducibility of the Mecholyl Test

CHARLES G. INGRAM M.B., Ch.B., D.A.1 and WALTER G. BROVINS M.D.2

1 Department of Physiology, St. Salvators College, University of St. Andrews, Fife, Scotland
2 Ypsilanti State Hospital, Ypsilanti, Michigan, U.S.A.

The reproducibility of certain parameters of the Mecholyl test was investigated in 23 psychiatric in-patients of mixed diagnoses. Each subject was tested on three occasions within one week, only those whose clinical state remained unchanged during that time being used.

Two changes were made in an effort to improve reproducibility: 1. methacholine dosage was adjusted to body weight (5 µg./kg./ minute), and 2. the drug was given intravenously over a period of six minutes, in order to overcome the variation in absorption rates likely with intramuscular injection.

All the drug response parameters chosen showed a high degree of reproducibility. The quotient—Area of decrease in Blood pressure Area of increase in heart rate, was the most reliable, with an intra-class correlation coefficient of .96.

Submitted on May 17, 1965






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1966 The Royal College of Psychiatrists.