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The British Journal of Psychiatry (1966) 112: 401-404. doi: 10.1192/bjp.112.485.401
© 1966 The Royal College of Psychiatrists
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Some Experiments in the Chemistry of Narcoleptic Sleep

J. I. EVANS M.B., Ch.B., D.P.M.1 and IAN OSWALD M.A., M.D., D.SC., D.P.M.2

1 Lecturer, Department of Psychiatry, University of Edinburgh
2 Visiting Professor of Psychiatry, University of Western Australia

The sleep of patients suffering from idiopathic narcolepsy differs from the sleep of normals in that the narcoleptic enters a phase of "paradoxical" sleep initially, while the normal enters a phase of orthodox sleep.

Narcoleptics are shown to be abnormally sensitive to 5 grams of laevo-tryptophan taken 15 minutes before retiring. The duration of the initial period of "paradoxical" sleep is doubled, and more often accompanied by a nightmare dream.

Submitted on July 15, 1965






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