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The British Journal of Psychiatry (1966) 112: 737-742. doi: 10.1192/bjp.112.488.737
© 1966 The Royal College of Psychiatrists
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Tegretol (Carbamazepine): A Controlled Trial of a New Anti-Convulsant

C. A. K. BIRD M.R.C.S., L.R.C.P., F.C.Path., D.Path.1, B. P. GRIFFIN M.A., M.R.C.S., L.R.C.P., D.P.M.2, J. M. MIKLASZEWSKA Med. Dipl.2, and A. W. GALBRAITH M.A., M.B., D.C.H.3

1 Consultant Group Pathologist, Macclesfield and District Hospitals
2 Cranage Hall Hospital, Holmes Chapel, Cheshire
3 Geigy Pharmaceutical Company

In a statistically controlled double-blind trial of Tegretol (carbamazepine) for eighteen months in 45 mentally subnormal in-patients suffering from grand mal epilepsy, Tegretol possessed an equivalent anticonvulsant action to phenobarbitone, sodium phenytoin and mysoline, given separately or in combination. Dose increase was carried out in 14 patients. Petit mal episodes were recorded. Possible changes in mood were looked for and throughout the trial extensive pathological screening was carried out.

Side-effects were uncommon and no adverse haematological or biochemical reaction was ascribed to the drug.

Submitted on August 2, 1965






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1966 The Royal College of Psychiatrists.