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The British Journal of Psychiatry (1967) 113: 183-193. doi: 10.1192/bjp.113.495.183
© 1967 The Royal College of Psychiatrists
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Plasma Levels of Imipramine and Desmethylimipramine during Therapy

J. P. MOODY Ph.D.1, A. C. TAIT M.B., M.R.C.P.(Ed.), D.P.H., D.P.M.2, and A. TODRICK M.A., Ph.D., F.R.I.C.3

1 Research Biochemist, Department of Clinical Research, Crichton Royal, Dumfries; Senior Biochemist, Royal Dundee Liff Hospital, by Dundee
2 Director of Clinical Research, Crichton Royal, Dumfries
3 Principal Biochemist, Crichton Royal, Dumfries

A method has been developed for the analysis of imipramine and desmethylimipramine in the plasma of patients receiving imipramine therapy. Following single oral doses of 50 mg. imipramine, only low concentrations of the two compounds were found in the plasma of volunteers. However, over a 16 hour period, progressive conversion of imipramine to DMI took place. During the first 5 to 6 weeks of imipramine therapy the plasma levels in patients increased, but the rate and extent of accumulation varied from individual to individual. In a survey of 24 patients receiving long-term imipramine therapy, considerable variations in the plasma imipramine and DMI levels were found which were not primarily related to the dosages given. These individual plasma levels were stable through a 24-hour period and when blood samples were taken one week and two months apart. The results are discussed in terms of present knowledge of the biochemical fate of imipramine in animals.

Submitted on March 16, 1966




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Copyright © 1967 The Royal College of Psychiatrists.