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The British Journal of Psychiatry (1967) 113: 1297-1308. doi: 10.1192/bjp.113.504.1297
© 1967 The Royal College of Psychiatrists
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Patterns of Salivary Flow in Depressive Illness and During Treatment

G. PALMAI B.Sc., M.B., B.S., D.T.M.&H., D.P.M.1, B. BLACKWELL M.A., M.D., D.P.M.2, A. E. MAXWELL M.A., M.Ed., Ph.D.3, and F. MORGENSTERN M.A., B.M., D.P.M.4

1 Registrar, The Maudsley Hospital, Denmark Hill, London, S.E.5., Lecturer, Department of Psychological Medicine, University of Leeds
2 Research Worker (Hon. Senior Registrar), The Maudsley Hospital, Denmark Hill, London, S.E.5
3 Statistician, The Maudsley Hospital, Denmark Hill, London, S.E.5
4 Research Worker, The Maudsley Hospital, Denmark Hill, London, S.E.5

Salivary flow was measured throughout the day and night in 20 female in-patients complaining of depression without diurnal variation in mood, and in 10 matched controls. Compared with controls, salivary flow for patients was diminished throughout the twenty-four hours, but the diurnal rhythm was normal, in contrast to the reversed rhythm previously seen in patients with early morning wakening and a diurnal variation in mood. Four patients treated with E.C.T. showed a steady return to normal salivary flow. Sixteen patients treated with imipramine also showed a similar, but not so complete, return to normal salivary flow. The possible mechanism and clinical significance of the effect of imipramine on salivation are examined and discussed.

Submitted on September 21, 1966




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1967 The Royal College of Psychiatrists.