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1 Assistant Psychiatrist, Whittingham Hospital, Preston, Lancashire
This paper describes an investigation into the frequency of a wide range of blood groups in a series of 500 patients admitted to hospital with some form of mental illness.
Previous work has suggested a possible association between blood group O and manic-depressive psychosis. An analysis of the present data adds some support for such an association. The numbers are small, but the adoption of strict diagnostic criteria has ensured a more homogeneous group of patients. The possibility of a causal effect is considered to be most unlikely. Racial stratification may be the answer, but further studies from different regions of the world, including the collection of sibship data, will be necessary before any definite conclusions can be reached. Other possibilities considered are a pleiotropic effect of blood group genes, and a maternal effect.
A word of warning is sounded about the over-eager acceptance in this field of the usual 5 per cent. and 1 per cent. levels of significance. Adopting this more cautious approach, the general conclusion is that there is no significant correlation between the ABO, MN, Rhesus and Kell blood groups and psychiatric disorders. However, there is the suggestion of an increased incidence of group O in manic-depressive psychosis, and further research on this possible association might be worth while.
Submitted on November 15, 1966
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