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The British Journal of Psychiatry (1967) 113: 1431-1432. doi: 10.1192/bjp.113.505.1431
© 1967 The Royal College of Psychiatrists
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A Trial of Fluphenazine Enanthate in Chronic Schizophrenia

JOHN MILLAR M.B., Ch.B., D.P.M.1 and G. R. DANIEL M.B., B.S.2

1 Consultant Psychiatrist, Carlton Hayes Hospital, Narborough, Leicester
2 Medical Adviser, E. R. Squibb & Sons Limited, Regal House, Twickenham, Middlesex

In a clinical trial on in-patient chronic schizophrenics, fluphenazine enanthate controlled 82 per cent. of the patients when given in doses of 1 ml. (25 mg.) every two weeks for six months. Over 25 per cent. showed moderate or marked improvement over their previous clinical state when they were on oral phenothiazines. Four patients previously receiving oral fluphenazine were definitely improved, and this suggested that they had not been taking all their tablets. Anti-Parkinson drugs were required by only 33 per cent. of the controlled cases after four months' treatment. This is an effective and time-saving preparation for the majority of schizophrenic in-patients and likely to be a most useful drug for those out-patients who are unreliable at taking their medication.

Submitted on November 30, 1966




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Arch Gen PsychiatryHome page
J. E. Groves and M. R. Mandel
The Long-Acting Phenothiazines
Arch Gen Psychiatry, July 1, 1975; 32(7): 893 - 900.
[Abstract] [PDF]




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Copyright © 1967 The Royal College of Psychiatrists.