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The British Journal of Psychiatry (1967) 113: 1433-1434. doi: 10.1192/bjp.113.505.1433
© 1967 The Royal College of Psychiatrists
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Double-Blind Comparison of Nortriptyline and Amitriptyline in Depressive Illness

M. R. LEAHY B.A., M.B., B.Ch., D.P.M.1 and IAN C. A. MARTIN M.B., Ch.B., D.P.M.2

1 Consultant Psychiatrist, St. James's Hospital, Leeds, 9
2 Senior Registrar, St. James's Hospital, Leeds, 9

No statistically significant difference in outcome was found as a result of treatment with either drug, although there is the suggestion that amitriptyline might be more effective in the treatment of reactive depressive illness. Both drugs were highly potent in reducing the depressive score ratings within their respective samples, and in view of this and previous experience with amitriptyline both should be considered as valuable anti-depressive preparations in clinical practice. No particular difference in the incidence of side-effects could be detected in the sampling used.

Submitted on September 25, 1966




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Copyright © 1967 The Royal College of Psychiatrists.