BJP Evidence-Based Mental Health
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

The British Journal of Psychiatry (1968) 114: 797-811. doi: 10.1192/bjp.114.512.797
© 1968 The Royal College of Psychiatrists
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BLESSED, G.
Right arrow Articles by ROTH, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BLESSED, G.
Right arrow Articles by ROTH, M.

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

G. BLESSED M.B., B.S., M.R.C.P.E., D.P.M.1, B. E. TOMLINSON M.D., F.R.C.P., F.C.Path.1, and MARTIN ROTH M.D., F.R.C.P., D.P.M.1

1 Medical Research Council Group on the Relation between Functional and Organic Psychiatric Illness, 11 Framlington Place, Newcastle upon Tyne 2, and the Department of Psychological Medicine, University of Newcastle upon Tyne.

1. The association between plaque counts in sections of cerebral cortex and measures of intellectual and personality functioning undertaken in elderly subjects during life has been studied.

2. There was no evidence that degenerative changes had contributed significantly to the causation of illness in patients with "functional" psychiatric disorders or delirious states.

3. There is a highly significant correlation between mean plaque counts and scores for dementia and performance in psychological tests. The findings suggest that psychological and pathological indices are closely related to one another, possibly through their common association with the underlying degenerative process in the brain.

4. Among severely demented subjects and those diagnosed clinically as "senile dements", correlations between psychological and pathological measures decline sharply. However, pathological differences between normal, mildly demented, and severely demented subjects appear to be of a quantitative nature. The possibility that there are qualitative differences in this group, inaccessible to present methods of examination, cannot be excluded.

Submitted on May 8, 1967




This article has been cited by other articles:


Home page
 JNMHome page
J. Sojkova, L. Beason-Held, Y. Zhou, Y. An, M. A. Kraut, W. Ye, L. Ferrucci, C. A. Mathis, W. E. Klunk, D. F. Wong, et al.
Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern?
J. Nucl. Med., September 1, 2008; 49(9): 1465 - 1471.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. Holtzer, J. Verghese, C. Wang, C. B. Hall, and R. B. Lipton
Within-Person Across-Neuropsychological Test Variability and Incident Dementia
JAMA, August 20, 2008; 300(7): 823 - 830.
[Abstract] [Full Text] [PDF]

Home page
 DementiaHome page
K. Betts Adams, M. J. McClendon, and K. A. Smyth
Personal losses and relationship quality in dementia caregiving
Dementia, August 1, 2008; 7(3): 301 - 319.
[Abstract] [PDF]

Home page
 Epidemiol RevHome page
J. J. Jalbert, L. A. Daiello, and K. L. Lapane
Dementia of the Alzheimer Type
Epidemiol. Rev., July 16, 2008; (2008) mxn008v1.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. R. Steinerman, M. Irizarry, N. Scarmeas, S. Raju, J. Brandt, M. Albert, D. Blacker, B. Hyman, and Y. Stern
Distinct Pools of {beta}-Amyloid in Alzheimer Disease-Affected Brain: A Clinicopathologic Study
Arch Neurol, July 1, 2008; 65(7): 906 - 912.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. J. Locascio, H. Fukumoto, L. Yap, T. Bottiglieri, J. H. Growdon, B. T. Hyman, and M. C. Irizarry
Plasma Amyloid {beta}-Protein and C-reactive Protein in Relation to the Rate of Progression of Alzheimer Disease
Arch Neurol, June 1, 2008; 65(6): 776 - 785.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. E. Zimmerman, J. W. Pan, H. P. Hetherington, M. J. Katz, J. Verghese, H. Buschke, C. A. Derby, and R. B. Lipton
Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults
Neurology, April 29, 2008; 70(18): 1594 - 1600.
[Abstract] [Full Text] [PDF]

Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
H. Gurvit, M. Emre, S. Tinaz, B. Bilgic, H. Hanagasi, H. Sahin, E. Gurol, J.T. Kvaloy, and H. Harmanci
The Prevalence of Dementia in an Urban Turkish Population
American Journal of Alzheimer's Disease and Other Dementias, March 1, 2008; 23(1): 67 - 76.
[Abstract] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
R. L. Ownby, A. Acevedo, D. G. Harwood, W. W. Barker, and R. Duara
Patterns of Depression in Spanish- and English-Speaking Patients With Alzheimer's Disease
J Geriatr Psychiatry Neurol, March 1, 2008; 21(1): 47 - 55.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
N. Raz, U. Lindenberger, P. Ghisletta, K. M. Rodrigue, K. M. Kennedy, and J. D. Acker
Neuroanatomical Correlates of Fluid Intelligence in Healthy Adults and Persons with Vascular Risk Factors
Cereb Cortex, March 1, 2008; 18(3): 718 - 726.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
D. F. Terry, P. Sebastiani, S. L. Andersen, and T. T. Perls
Disentangling the Roles of Disability and Morbidity in Survival to Exceptional Old Age
Arch Intern Med, February 11, 2008; 168(3): 277 - 283.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
C. M. Roe, C. Xiong, E. Grant, J. P. Miller, and J. C. Morris
Education and Reported Onset of Symptoms Among Individuals With Alzheimer Disease
Arch Neurol, January 1, 2008; 65(1): 108 - 111.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
C. Reitz, M.-X. Tang, J. Manly, R. Mayeux, and J. A. Luchsinger
Hypertension and the Risk of Mild Cognitive Impairment
Arch Neurol, December 1, 2007; 64(12): 1734 - 1740.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
N. Scarmeas, J. Brandt, D. Blacker, M. Albert, G. Hadjigeorgiou, B. Dubois, D. Devanand, L. Honig, and Y. Stern
Disruptive Behavior as a Predictor in Alzheimer Disease
Arch Neurol, December 1, 2007; 64(12): 1755 - 1761.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. Xu, P. G. Antuono, J. Jones, Y. Xu, G. Wu, D. Ward, and S. -J. Li
Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects
Neurology, October 23, 2007; 69(17): 1650 - 1656.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. B. Hall, C. Derby, A. LeValley, M. J. Katz, J. Verghese, and R. B. Lipton
Education delays accelerated decline on a memory test in persons who develop dementia
Neurology, October 23, 2007; 69(17): 1657 - 1664.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J. Verghese, C. Wang, R. B Lipton, R. Holtzer, and X. Xue
Quantitative gait dysfunction and risk of cognitive decline and dementia
J. Neurol. Neurosurg. Psychiatry, September 1, 2007; 78(9): 929 - 935.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
N. Nelissen, M. Vandenbulcke, K. Fannes, A. Verbruggen, R. Peeters, P. Dupont, K. Van Laere, G. Bormans, and R. Vandenberghe
A{beta} amyloid deposition in the language system and how the brain responds
Brain, August 1, 2007; 130(8): 2055 - 2069.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. P. Kiel, J. Magaziner, S. Zimmerman, L. Ball, B. A. Barton, K. M. Brown, J. P. Stone, D. Dewkett, and S. J. Birge
Efficacy of a Hip Protector to Prevent Hip Fracture in Nursing Home Residents: The HIP PRO Randomized Controlled Trial
JAMA, July 25, 2007; 298(4): 413 - 422.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
S. K. Inouye, Y. Zhang, R. N. Jones, D. K. Kiely, F. Yang, and E. R. Marcantonio
Risk Factors for Delirium at Discharge: Development and Validation of a Predictive Model
Arch Intern Med, July 9, 2007; 167(13): 1406 - 1413.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
D. Blacker, H. Lee, A. Muzikansky, E. C. Martin, R. Tanzi, J. J. McArdle, M. Moss, and M. Albert
Neuropsychological Measures in Normal Individuals That Predict Subsequent Cognitive Decline
Arch Neurol, June 1, 2007; 64(6): 862 - 871.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. E. Galvin, H. Malcom, D. Johnson, and J. C. Morris
Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease
Neurology, May 29, 2007; 68(22): 1895 - 1901.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. B. Rodin and S. G. Mohile
A Practical Approach to Geriatric Assessment in Oncology
J. Clin. Oncol., May 10, 2007; 25(14): 1936 - 1944.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
G. S. Zubenko, W. N. Zubenko, B. S. Maher, and N. S. Wolf
Reduced Age-Related Cataracts Among Elderly Persons Who Reach Age 90 With Preserved Cognition: A Biomarker of Successful Aging?
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2007; 62(5): 500 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
A. Kerr and D. Kay
Sir Martin Roth FRS: An appreciation
The British Journal of Psychiatry, May 1, 2007; 190(5): 375 - 378.
[Full Text] [PDF]

Home page
 AJGPHome page
G. S. Zubenko, H. B. Hughes III, W. N. Zubenko, and B. S. Maher
Genome Survey for Loci That Influence Successful Aging: Results at 10-cM Resolution
Am J Geriatr Psychiatry, March 1, 2007; 15(3): 184 - 193.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
A. T. Blaszczyk and M. Mathys
Treatment of Cognitive Decline and Psychiatric Disturbances Associated With Alzheimer's Dementia
Journal of Pharmacy Practice, February 1, 2007; 20(1): 13 - 28.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
E. M. Balk, G. Raman, A. Tatsioni, M. Chung, J. Lau, and I. H. Rosenberg
Vitamin B6, B12, and Folic Acid Supplementation and Cognitive Function: A Systematic Review of Randomized Trials
Arch Intern Med, January 8, 2007; 167(1): 21 - 30.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
N. Barzilai, G. Atzmon, C. A. Derby, J. M. Bauman, and R. B. Lipton
A genotype of exceptional longevity is associated with preservation of cognitive function
Neurology, December 26, 2006; 67(12): 2170 - 2175.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. M. Williams, C. Xiong, J. C. Morris, and J. E. Galvin
Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease
Neurology, December 12, 2006; 67(11): 1935 - 1941.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
M. Tettamanti, M. T. Garri, A. Nobili, E. Riva, and U. Lucca
Low Folate and the Risk of Cognitive and Functional Deficits in the Very Old: The Monzino 80-plus Study
J. Am. Coll. Nutr., December 1, 2006; 25(6): 502 - 508.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
T. G. Fong, S. T. Bogardus Jr.,, A. Daftary, E. Auerbach, H. Blumenfeld, S. Modur, L. Leo-Summers, J. Seibyl, and S. K. Inouye
Cerebral Perfusion Changes in Older Delirious Patients Using 99mTc HMPAO SPECT
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2006; 61(12): 1294 - 1299.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
R. N. Jones, F. M. Yang, Y. Zhang, D. K. Kiely, E. R. Marcantonio, and S. K. Inouye
Does Educational Attainment Contribute to Risk for Delirium? A Potential Role for Cognitive Reserve
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2006; 61(12): 1307 - 1311.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
B. G. Vickrey, B. S. Mittman, K. I. Connor, M. L. Pearson, R. D. Della Penna, T. G. Ganiats, R. W. DeMonte Jr., J. Chodosh, X. Cui, S. Vassar, et al.
The Effect of a Disease Management Intervention on Quality and Outcomes of Dementia Care: A Randomized, Controlled Trial.
Ann Intern Med, November 21, 2006; 145(10): 713 - 726.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. Goedert and M. G. Spillantini
A Century of Alzheimer's Disease
Science, November 3, 2006; 314(5800): 777 - 781.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. R. Hodges
Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects.
Brain, November 1, 2006; 129(Pt 11): 2811 - 2822.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. Wang, L. Ho, Z. Zhao, I. Seror, N. Humala, D. L. Dickstein, M. Thiyagarajan, S. S. Percival, S. T. Talcott, and G. M. Pasinetti
Moderate consumption of Cabernet Sauvignon attenuates A{beta} neuropathology in a mouse model of Alzheimer's disease
FASEB J, November 1, 2006; 20(13): 2313 - 2320.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. Gamaldo, A. Moghekar, S. Kilada, S. M. Resnick, A. B. Zonderman, and R. O'Brien
Effect of a clinical stroke on the risk of dementia in a prospective cohort
Neurology, October 24, 2006; 67(8): 1363 - 1369.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. J. Visser, A. Kester, J. Jolles, and F. Verhey
Ten-year risk of dementia in subjects with mild cognitive impairment.
Neurology, October 10, 2006; 67(7): 1201 - 1207.
[Abstract] [Full Text] [PDF]

Home page
 J Aging HealthHome page
C. S. Williams, M. E. Tinetti, S. V. Kasl, and P. N. Peduzzi
The Role of Pain in the Recovery of Instrumental and Social Functioning After Hip Fracture.
J Aging Health, October 1, 2006; 18(5): 743 - 762.
[Abstract] [PDF]

Home page
 RadiologyHome page
A. Ramani, J. H. Jensen, and J. A. Helpern
Quantitative MR Imaging in Alzheimer Disease
Radiology, October 1, 2006; 241(1): 26 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
K. Stavitsky, A. M. Brickman, N. Scarmeas, R. L. Torgan, M.-X. Tang, M. Albert, J. Brandt, D. Blacker, and Y. Stern
The progression of cognition, psychiatric symptoms, and functional abilities in dementia with lewy bodies and Alzheimer disease.
Arch Neurol, October 1, 2006; 63(10): 1450 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. W. Zhu, N. Scarmeas, R. Torgan, M. Albert, J. Brandt, D. Blacker, M. Sano, and Y. Stern
Longitudinal study of effects of patient characteristics on direct costs in Alzheimer disease
Neurology, September 26, 2006; 67(6): 998 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 AJGPHome page
J. T. O'Brien
Vascular Cognitive Impairment
Am J Geriatr Psychiatry, September 1, 2006; 14(9): 724 - 733.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
R. D. Terry
Alzheimer's Disease and the Aging Brain
J Geriatr Psychiatry Neurol, September 1, 2006; 19(3): 125 - 128.
[Abstract] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
B. Reisberg
Diagnostic Criteria in Dementia: A Comparison of Current Criteria, Research Challenges, and Implications for DSM-V
J Geriatr Psychiatry Neurol, September 1, 2006; 19(3): 137 - 146.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
D. K. Johnson, C. H. Wilkins, and J. C. Morris
Accelerated weight loss may precede diagnosis in Alzheimer disease.
Arch Neurol, September 1, 2006; 63(9): 1312 - 1317.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
O. L. Lopez, J. T. Becker, R. A. Sweet, F. J. Martin-Sanchez, and R. L. Hamilton
Lewy bodies in the amygdala increase risk for major depression in subjects with Alzheimer disease.
Neurology, August 22, 2006; 67(4): 660 - 665.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
M. H. Tabert, J. J. Manly, X. Liu, G. H. Pelton, S. Rosenblum, M. Jacobs, D. Zamora, M. Goodkind, K. Bell, Y. Stern, et al.
Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment.
Arch Gen Psychiatry, August 1, 2006; 63(8): 916 - 924.
[Abstract] [Full Text] [PDF]

Home page
 AJGPHome page
J. Vilalta-Franch, J. Garre-Olmo, S. Lopez-Pousa, A. Turon-Estrada, M. Lozano-Gallego, M. Hernandez-Ferrandiz, I. Pericot-Nierga, and R. Feijoo-Lorza
Comparison of Different Clinical Diagnostic Criteria for Depression in Alzheimer Disease
Am J Geriatr Psychiatry, July 1, 2006; 14(7): 589 - 597.
[Abstract] [Full Text] [PDF]

Home page
 Age AgeingHome page
S. Lopez-Pousa, J. G. Olmo, J. V. Franch, A. T. Estrada, O. S. Cors, I. P. Nierga, and E. Gelada-Batlle
Comparative analysis of mortality in patients with Alzheimer's disease treated with donepezil or galantamine.
Age Ageing, July 1, 2006; 35(4): 365 - 371.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. W. Hogue Jr, T. Hershey, D. Dixon, R. Fucetola, A. Nassief, K. E. Freedland, B. Thomas, and K. Schechtman
Preexisting cognitive impairment in women before cardiac surgery and its relationship with C-reactive protein concentrations.
Anesth. Analg., June 1, 2006; 102(6): 1602 - 1608.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. W. Zhu, N. Scarmeas, R. Torgan, M. Albert, J. Brandt, D. Blacker, M. Sano, and Y. Stern
Clinical features associated with costs in early AD: Baseline data from the Predictors Study
Neurology, April 11, 2006; 66(7): 1021 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. Verghese, A. LeValley, C. Derby, G. Kuslansky, M. Katz, C. Hall, H. Buschke, and R. B. Lipton
Leisure activities and the risk of amnestic mild cognitive impairment in the elderly
Neurology, March 28, 2006; 66(6): 821 - 827.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
N Scarmeas, S M Albert, J J Manly, and Y Stern
Education and rates of cognitive decline in incident Alzheimer's disease.
J. Neurol. Neurosurg. Psychiatry, March 1, 2006; 77(3): 308 - 316.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
D. K. Kiely, R. N. Jones, M. A. Bergmann, K. M. Murphy, E. J. Orav, and E. R. Marcantonio
Association between delirium resolution and functional recovery among newly admitted postacute facility patients.
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2006; 61(2): 204 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
A. S. Fleisher, W. S. Houston, L. T. Eyler, S. Frye, C. Jenkins, L. J. Thal, and M. W. Bondi
Identification of Alzheimer Disease Risk by Functional Magnetic Resonance Imaging
Arch Neurol, December 1, 2005; 62(12): 1881 - 1888.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
L. A Boothby and P. L Doering
Vitamin C and Vitamin E for Alzheimer's Disease
Ann. Pharmacother., December 1, 2005; 39(12): 2073 - 2079.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. C. Irizarry, M. E. Gurol, S. Raju, R. Diaz-Arrastia, J. J. Locascio, M. Tennis, B. T. Hyman, J. H. Growdon, S. M. Greenberg, and T. Bottiglieri
Association of homocysteine with plasma amyloid {beta} protein in aging and neurodegenerative disease
Neurology, November 8, 2005; 65(9): 1402 - 1408.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. J. Manly, S. Bell-McGinty, M.-X. Tang, N. Schupf, Y. Stern, and R. Mayeux
Implementing Diagnostic Criteria and Estimating Frequency of Mild Cognitive Impairment in an Urban Community
Arch Neurol, November 1, 2005; 62(11): 1739 - 1746.
[Abstract] [Full Text] [PDF]