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The British Journal of Psychiatry (1968) 114: 1167-1174. doi: 10.1192/bjp.114.514.1167
© 1968 The Royal College of Psychiatrists
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Chromosome Findings in Chronic Psychotic Patients

J. M. ANDERS M.Sc.1, G. JAGIELLO A.B., M.D.2, P. E. POLANI M.D., F.R.C.P., D.C.H.3, F. GIANNELLI M.D.4, J. L. HAMERTON B.Sc.4, and D. M. LEIBERMAN B.Sc., M.D., M.R.C.P., D.P.M.5

1 Research Assistant, Institute of Cardiology, Wimpole Street, London, W.1
2 United States Public Health Special Fellow, 1 F3 HD-8443 -01 REP, Senior Lecturer, Paediatric Research Unit, Guy's Hospital Medical School, London, S.E.1
3 Prince Philip Professor of Paediatric Research in the University of London, Paediatric Research Unit, Guy's Hospital Medical School, London, S.E.1
4 Senior Lecturer, Paediatric Research Unit, Guy's Hospital Medical School, London, S.E.1
5 Consultant Psychiatrist, Bexley Hospital, Dartford Heath, Bexley, Kent

529 male and 445 female schizophrenics were studied, initially by nuclear sexing and subsequently by chromosome analysis where necessary. Six of the males were chromatin positive, with a count of forty-seven chromosomes and presumed XXY sex-chromosome constitution. One female had a presumed XXX sex-chromosome constitution, one had an additional minute fragment, and two had morphological autosomal variants. A wide range of counts was found in the other fifty women studied chromosomally, but this was believed to be due to the high average age of the patients.

Submitted on June 30, 1967




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