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The British Journal of Psychiatry (1970) 116: 179-183. doi: 10.1192/bjp.116.531.179
© 1970 The Royal College of Psychiatrists
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Serum Folate and Vitamin B12 in Epileptics with and without Mental Illness

R. P. SNAITH M.D., D.C.H., D.P.M.1, S. MEHTA M.D., M.R.C.P.E.2, and A. H. RABY A.I.M.L.T.3

1 Consultant Psychiatrist, Stanley Royd Hospital, Aberford Road, Wakefield.
2 Registrar, Stanley Royd Hospital.
3 Senior Technician, Department of Pathology, Pinderfields and Stanley Royd Hospitals, Wakefield.

The relationship between disturbed vitamin B12 and folic acid metabolism, anticonvulsant drug medication, and mental illness has been re-examined in a series of epileptic patients.

Significantly low levels of serum folate were found in all epileptic patients. Moreover epileptic patients with mental illness had significantly lower serum folate levels than epileptic patients without mental illness, although no particular type of psychiatric syndrome seemed to be incriminated. No significant findings were found in relationship to serum vitamin B12 levels.

The authors consider possible alternatives in the interpretation of these findings.

Submitted on December 9, 1968






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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1970 The Royal College of Psychiatrists.