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The British Journal of Psychiatry (1970) 116: 615-619. doi: 10.1192/bjp.116.535.615
© 1970 The Royal College of Psychiatrists
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Pharmacological and Clinical Problems of Lithium Prophylaxis

M. SCHOU M.D.1, P. C. BAASTRUP M.D.2, P. GROF M.D.3, P. WEIS Ph.D.4, and J. ANGST M.D.5

1 Psychopharmacology Research Unit, Aarhus University Psychiatric Institute, 8240 Risskov, Denmark
2 Psychiatric Hospital, 2600 Glostrup, Denmark
3 Psychiatric Research Institute, Prague, Czechoslovakia
4 Pharmazeutisches Department, J. R. Geigy AG, Basel, Switzerland
5 Psychiatrische Universitätsklinik, CH-8008 Zürich, Lenggstrasse 31, Switzerland

Lithium is an active prophylactic agent in recurrent affective disorders. Systematic use leads to improvement of the disease course in most patients, but there are some who do not respond. Lithium treatment may be accompanied by various side effects, and if the drug is given in overdose and without proper control, serious intoxications may be produced. Lithium exerts little effect on normal mental processes.

The prophylactic use of lithium requires sufficiently weighty indication. As with any other treatment, the disadvantages and risks of giving lithium must be weighed against the disadvantages and risks of not giving it. It is important that the patients are motivated and well instructed, and patients and doctors must be prepared to observe the practical measures necessary for a successful outcome of the treatment.

Submitted on March 3, 1969




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