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The British Journal of Psychiatry (1970) 117: 267-274. doi: 10.1192/bjp.117.538.267
© 1970 The Royal College of Psychiatrists
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Genetic Findings and Methodological Considerations in Manic Depressive Disease

GEORGE WINOKUR M.D.1

1 Professor of Psychiatry, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110

Evidence is presented for X-linked dominant transmission in manic depressive disease. This transmission accounts for the presence or absence of an affective disease. The quality of the disease, i.e. whether or not it contains mania, is possibly determined by a second genetic factor.

Methodological considerations concerning family studies are discussed. A method for determining whether the second genetic factor may be linked with a known genetic marker is presented.

Submitted on July 17, 1969




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