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The British Journal of Psychiatry (1971) 119: 33-38. doi: 10.1192/bjp.119.548.33
© 1971 The Royal College of Psychiatrists
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Unipolar and Bipolar Primary Affective Disorder

ROBERT A. WOODRUFF Jr. M.D.1, SAMUEL B. GUZE M.D.2, and PAULA J. CLAYTON M.D.3

1 Associate Professor of Psychiatry, Washington University, School of Medicine, St. Louis, Missouri 63110, U.S.A.
2 Professor of Psychiatry, Washington University, School of Medicine, St. Louis, Missouri 63110, U.S.A.
3 Assistant Professor of Psychiatry, Washington University, School of Medicine, St. Louis, Missouri 63110, U.S.A.

One hundred and fifty-eight patients with primary affective disorder, all seen in an outpatient setting, were investigated with regard to bipolar versus unipolar illness, early onset versus late onset unipolar illness, and chronic versus episodic course among unipolar patients. Statistically significant differences, particularly in family history data, serve as evidence of the validity of separating bipolar from unipolar cases, as well as the validity of separating early-onset unipolar cases from those of late onset. The number of chronic cases available for investigation was small, and statistical comparisons were not possible. The results, however, suggest that patients with chronic, unremitting depression over a period of many years may form a distinct group.

Submitted on September 7, 1970




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Copyright © 1971 The Royal College of Psychiatrists.