The British Journal of Psychiatry (1972) 120: 219-222. doi: 10.1192/bjp.120.555.219
© 1972 The Royal College of Psychiatrists
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Urinary Creatinine in Drug-Excretion Studies in Chronic Schizophrenics

S. SVED Ph.D.1, A. PERALES M.D.2, and H. -P. HOULE 3

1 Research Biochemist, Institut de Recherches Psychiatriques de Joliette, 1000, boul. Sainte-Anne, Joliette, Quebec, Canada
2 Hospital del Nina, Av. Brasil 600, Lima, Peru
3 Research Assistant, Institut de Recherches Psychiatriques de Joliette, 1000, boul. Sainte-Anne, Joliette, Quebec, Canada

Urinary output of creatinine in normal and schizophrenic subjects was found to be sufficiently constant during the morning to be used as a basis for drug excretion rates. Actual timing of the urine specimens was of no value in schizophrenics and alcoholics. The lowest dispersion in the rate of drug excretion in a group of chronic schizophrenics was obtained when this value was expressed on the basis of creatinine output corrected for body weight.

Submitted on May 10, 1971




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