The British Journal of Psychiatry (1972) 120: 507-509. doi: 10.1192/bjp.120.558.507
© 1972 The Royal College of Psychiatrists
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Effect of Shape of Medication in Treatment of Anxiety States

M. Z. HUSSAIN B.Sc., M.B., B.S., M.R.C.Psych.1

1 Victoria Union Hospital, 1200 24th Street West, Prince Albert, Saskatchewan, Canada

Fourty-four patients with anxiety state were treated with chlordiazepoxide, which was administered in tablet and in capsule forms. Every patient received two weeks' treatment with each form according to random crossover programme. The patients were assessed fort-nightly on physician's ratings and weekly self-ratings. Preference for capsules was shown by increased consumption rate and on the rating scales. The symptoms of anxiety, irritability, phobias and broken sleep improved significantly on capsules on patients' self-ratings.

Results indicate that the shape of medication. may play a part in the response to drug.

Submitted on October 26, 1971




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A. J M de Craen, P. J Roos, A L. de Vries, and J. Kleijnen
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[Abstract] [Full Text]