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The British Journal of Psychiatry 129: 227-232 (1976)
© 1976 The Royal College of Psychiatrists

Platelet monoamine oxidase in schizophrenia and manic-depressive illness

RH Belmaker, K Ebbesen, R Ebstein and R Rimon

Monoamine oxidase (MAO) is an important enzyme in the catabolism of brain biogenic amines. Platelet MAO has been reported to be moderately reduced in manic-depressive patients and markedly reduced in schizophrenic patients. This enzyme's activity has been shown to be under a large degree of genetic control and has been proposed as a 'genetic marker' in schizophrenia. A transcultural replication of the finding of low platelet MAO in schizophrenia and manic-depressive illness was carried out at the Jerusalem Mental Health Centre. Manic- depressive patients were found to have higher platelet MAO activity than schizophrenic patients, as reported previously, but control individuals were as low as the schizophrenic patients. It is unlikely that platelet MAO activity is a transculturally-valid marker for schizophrenia.


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 Journal of Research in Crime and DelinquencyHome page
L. ELLIS
Monoamine Oxidase and Criminality: Identifying an Apparent Biological Marker for Antisocial Behavior
Journal of Research in Crime and Delinquency, May 1, 1991; 28(2): 227 - 251.
[Abstract] [PDF]


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Copyright © 1976 The Royal College of Psychiatrists.