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The British Journal of Psychiatry 130: 144-147 (1977)
© 1977 The Royal College of Psychiatrists

Plasma levels of antidiuretic hormone in patients receiving prolonged lithium therapy

PL Padfield, SJ Park, JJ Morton and AE Braidwood

Among 18 patients receiving prophylactic, long-term lithium treatment for manic-depressive psychosis, a high incidence of increased thirst and frequency of micturition (60-70 per cent) was noted on direct questioning. Symptoms arose at varying times after the start of lithium therapy; in no patient did symptoms antedate the use of the drug. Plasma levels of antidiuretic hormone were found, on average, to be higher than in normal control subjects for a given level of plasma osmolality, although the scatter of results was wide. It is suggested that elevation of antidiuretic hormone occurs as a compensatory mechansims for the polyuria which is a common feature of long-term lithium treatment. The more florid form of nephrogenic diabetes insipidus occasionally seen in lithium takers seems likely to be due to a different mechanism from the more common mild polyuria.


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G.-H. Kim, N. W. Choi, J.-Y. Jung, J.-H. Song, C. H. Lee, C. M. Kang, and M. A. Knepper
Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2
Am J Physiol Renal Physiol, April 1, 2008; 294(4): F702 - F709.
[Abstract] [Full Text] [PDF]


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Copyright © 1977 The Royal College of Psychiatrists.