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The British Journal of Psychiatry 131: 582-586 (1977)
© 1977 The Royal College of Psychiatrists

Hormone responses to methylamphetamine in depression: a new approach to the noradrenaline depletion hypothesis

SA Checkley and JL Crammer

The corticosteroid response to methylamphetamine was lower in ten patients when they were depressed than when they were recovered (P less than .026). The growth hormone responses to the same injection in the depressed and recovered states were not significantly different. This pattern of responses is seen in normal subjects after blockade of alpha adrenergic receptors. These findings may indicate a functional deficiency of noradrenaline at alpha adrenergic receptors in these patients during the time they are depressed.


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M. D. Devous, M. H. Trivedi, and A. J. Rush
Regional Cerebral Blood Flow Response to Oral Amphetamine Challenge in Healthy Volunteers
J. Nucl. Med., April 1, 2001; 42(4): 535 - 542.
[Abstract] [Full Text]


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Copyright © 1977 The Royal College of Psychiatrists.