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The British Journal of Psychiatry 132: 145-148 (1978)
© 1978 The Royal College of Psychiatrists

Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment

D Lichtshtein, J Dobkin, RP Ebstein, J Biederman, R Rimon and RH Belmaker

Gamma-aminobutyric acid (GABA) levels in the CSF were measured in 9 normal individuals, 17 drug-free schizophrenic patients and 10 of these same schizophrenic patients after neuroleptic treatment. There was no significant difference between CSF level of GABA in the control group compared to those in schizophrenic patients; however, 6 of the 7 lowest GABA levels were from schizophrenic patients. There was a significant decline of 12 per cent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment.


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[Abstract] [PDF]


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Copyright © 1978 The Royal College of Psychiatrists.