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The British Journal of Psychiatry 133: 123-129 (1978)
© 1978 The Royal College of Psychiatrists

Recurrent unipolar depressions with a 48-hour cycle: report of a case

AJ Gelenberg, GL Klerman, EL Hartmann and P Salt

Since 1804 there have been twelve case reports of patients with mood disorders showing a regular periodicity of 48 hours, eight bipolar and four unipolar. This paper describes an additional patient, a 57-year- old man with a 48-hour unipolar cycle. Although his 24-hour serum cortisol pattern was abnormal, there were few clear-cut biological abnormalities. Possible mechanisms are discussed, and comparisons made with previous reports of similar patients.




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1978 The Royal College of Psychiatrists.