The British Journal of Psychiatry 134: 382-389 (1979)
© 1979 The Royal College of Psychiatrists

A new depression scale designed to be sensitive to change

SA Montgomery and M Asberg

The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described. Ratings of 54 English and 52 Swedish patients on a 65 item comprehensive psychopathology scale were used to identify the 17 most commonly occurring symptoms in primary depressive illness in the combined sample. Ratings on these 17 items for 64 patients participating in studies of four different antidepressant drugs were used to create a depression scale consisting of the 10 items which showed the largest changes with treatment and the highest correlation to overall change. The inner-rater reliability of the new depression scale was high. Scores on the scale correlated significantly with scores on a standard rating scale for depression, the Hamilton Rating Scale (HRS), indicating its validity as a general severity estimate. Its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change. The practical and ethical implications in terms of smaller sample sizes in clinical trials are discussed.

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				D Devos, P Krystkowiak, F Clement, K Dujardin, O Cottencin, N Waucquier, K Ajebbar, B Thielemans, M Kroumova, A Duhamel, et al. Improvement of gait by chronic, high doses of methylphenidate in patients with advanced Parkinson's disease J. Neurol. Neurosurg. Psychiatry, May 1, 2007; 78(5): 470 - 475. [Abstract] [Full Text] [PDF]

				M D Gjerstad, T Wentzel-Larsen, D Aarsland, and J P Larsen Insomnia in Parkinson's disease: frequency and progression over time J. Neurol. Neurosurg. Psychiatry, May 1, 2007; 78(5): 476 - 479. [Abstract] [Full Text] [PDF]

				J. M. Noel ASHP Therapeutic Position Statement on the Use of Second-Generation Antipsychotic Medications in the Treatment of Adults with Psychotic Disorders Am. J. Health Syst. Pharm., April 15, 2007; 64(8): 863 - 876. [Full Text] [PDF]

				L. Shi, H. Ascher-Svanum, B. Zhu, D. Faries, W. Montgomery, and S. R. Marder Characteristics and Use Patterns of Patients Taking First-Generation Depot Antipsychotics or Oral Antipsychotics for Schizophrenia Psychiatr Serv, April 1, 2007; 58(4): 482 - 488. [Abstract] [Full Text] [PDF]

				D. J. Miklowitz, M. W. Otto, E. Frank, N. A. Reilly-Harrington, S. R. Wisniewski, J. N. Kogan, A. A. Nierenberg, J. R. Calabrese, L. B. Marangell, L. Gyulai, et al. Psychosocial Treatments for Bipolar Depression: A 1-Year Randomized Trial From the Systematic Treatment Enhancement Program Arch Gen Psychiatry, April 1, 2007; 64(4): 419 - 426. [Abstract] [Full Text] [PDF]

				P. Scherer, I.K. Penner, A. Rohr, H. Boldt, I. Ringel, H. Wilke-Burger, E. Burger-Deinerth, K. Isakowitsch, M. Zimmermann, S. Zahrnt, et al. The Faces Symbol Test, a newly developed screening instrument to assess cognitive decline related to multiple sclerosis: first results of the Berlin Multi-Centre FST Validation Study Multiple Sclerosis, April 1, 2007; 13(3): 402 - 411. [Abstract] [PDF]

				D. S. Salkever, M. C. Karakus, E. P. Slade, C. M. Harding, R. L. Hough, R. A. Rosenheck, M. S. Swartz, C. Barrio, and A. M. Yamada Measures and Predictors of Community-Based Employment and Earnings of Persons With Schizophrenia in a Multisite Study Psychiatr Serv, March 1, 2007; 58(3): 315 - 324. [Abstract] [Full Text] [PDF]

				N. F. Gould, M. K. Holmes, B. D. Fantie, D. A. Luckenbaugh, D. S. Pine, T. D. Gould, N. Burgess, H. K. Manji, and C. A. Zarate Jr. Performance on a Virtual Reality Spatial Memory Navigation Task in Depressed Patients Am J Psychiatry, March 1, 2007; 164(3): 516 - 519. [Abstract] [Full Text] [PDF]

				S. R. Chamberlain, N. A. Fineberg, L. A. Menzies, A. D. Blackwell, E. T. Bullmore, T. W. Robbins, and B. J. Sahakian Impaired Cognitive Flexibility and Motor Inhibition in Unaffected First-Degree Relatives of Patients With Obsessive-Compulsive Disorder Am J Psychiatry, February 1, 2007; 164(2): 335 - 338. [Abstract] [Full Text] [PDF]

				A. T. Blaszczyk and M. Mathys Treatment of Cognitive Decline and Psychiatric Disturbances Associated With Alzheimer's Dementia Journal of Pharmacy Practice, February 1, 2007; 20(1): 13 - 28. [Abstract] [PDF]