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The British Journal of Psychiatry 135: 73-76 (1979)
© 1979 The Royal College of Psychiatrists

Amitriptyline: comparison of three different dosage schedules in neurotic depression

D De Maio and A Levi-Minzi

Three groups of neurotic depressed patients were treated with amitriptyline, one group receiving the customary three daily doses, another a single dose in the morning, and the third a single dose at night. All three groups showed significant decrements of total scores on the Hamilton Scale for Depression and the Zung Self-Rating Depression Scale without significant differences. Patients taking the drug at night showed a lower incidence of side effects.