BJP College Seminars Series
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cohen, S. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cohen, S. I.

The British Journal of Psychiatry 136: 120-124 (1980)
© 1980 The Royal College of Psychiatrists

Cushing's syndrome: a psychiatric study of 29 patients

SI Cohen

Among a consecutive unselected series of 29 patients with Cushing's syndrome 21 had bilateral adrenal hyperplasia and 8 had tumours. Twenty- five (86 per cent) were significantly depressed; three of the tumour patients, but only one of the hyperplasia group were free of symptoms so that if there are no psychiatric symptoms there is a three in four chance that the patient has a tumour. There was a family history of depression or suicide or a history of early bereavement or separation in half the cases. In six of the hyperplasia patients a major emotional disturbance had preceded the onset, and in five this was a loss. The severity of the depression was not related to the level of circulating cortisol. The depression was rapidly relieved when the tumour or hyperplastic glands were removed. Depression in Cushing's syndrome might result from a substance other than cortisol produced by the adrenal under excessive pituitary and/or hypothalamic stimulation, which could play a part in the aetiology of depressive illness in general.


This article has been cited by other articles:


Home page
 Recent Prog Horm ResHome page
J. R. Seckl, N. M. Morton, K. E. Chapman, and B. R. Walker
Glucocorticoids and 11beta-Hydroxysteroid Dehydrogenase in Adipose Tissue
Recent Prog. Horm. Res., January 1, 2004; 59(1): 359 - 393.
[Abstract] [Full Text]

Home page
 Psychosom. Med.Home page
M. N. Starkman, B. Giordani, S. Berent, M. A. Schork, and D. E. Schteingart
Elevated Cortisol Levels in Cushing's Disease Are Associated With Cognitive Decrements
Psychosom Med, November 1, 2001; 63(6): 985 - 993.
[Abstract] [Full Text] [PDF]

Home page
 Psychosom. Med.Home page
O. M. Wolkowitz and V. I. Reus
Treatment of Depression With Antiglucocorticoid Drugs
Psychosom Med, September 1, 1999; 61(5): 698 - 711.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. D. Dorn, E. S. Burgess, T. C. Friedman, B. Dubbert, P. W. Gold, and G. P. Chrousos
The Longitudinal Course of Psychopathology in Cushing's Syndrome after Correction of Hypercortisolism
J. Clin. Endocrinol. Metab., March 1, 1997; 82(3): 912 - 919.
[Abstract] [Full Text] [PDF]

Home page
 J PsychopharmacolHome page
A. L. Malizia and P. K. Bridges
The management of treatment-resistant affective disorder: clinical perspectives
J Psychopharmacol, January 1, 1992; 6(2): 145 - 155.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1980 The Royal College of Psychiatrists.