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The British Journal of Psychiatry 136: 154-160 (1980)
© 1980 The Royal College of Psychiatrists

A double-blind comparison of dothiepin and amitriptyline in patients with primary affective disorder: serum levels and clinical response

J Mendlewicz, P Linkowski and JA Rees

In a double-blind parallel group study, thirty-two patients suffering from a primary affective disorder received either dothiepin or amitriptyline. Serum concentrations of total dothiepin plus northiaden or amitriptyline and nortriptyline were estimated. A similar therapeutic response was seen with both drugs but there was no correlation with serum concentrations of amitriptyline or nortriptyline, whereas serum dothiepin correlated positively with clinical response.


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Copyright © 1980 The Royal College of Psychiatrists.