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The British Journal of Psychiatry 137: 337-342 (1980)
© 1980 The Royal College of Psychiatrists

Linkage between glucose-6-phosphate dehydrogenase deficiency and manic- depressive psychosis

J Mendlewicz, P Linkowski and J Wilmotte

Hereditary has been shown to be an important factor in the aetiology of manic-depressive psychosis. Recent linkage studies with colour blindness have suggested the presence of an X-linked dominant gene in the transmission of manic-depressive psychosis. We report here positive evidence of a linkage between manic-depressive psychosis and glucose-6- phosphate dehydrogenase deficiency in an informative family assorting for both traits. These results strengthen previous linkage studies in affective illness and support the hypothesis of X-linkage in a subgroup of manic-depressive psychosis.


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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1980 The Royal College of Psychiatrists.