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The British Journal of Psychiatry 137: 346-351 (1980)
© 1980 The Royal College of Psychiatrists

Noradrenergic overactivity in chronic schizophrenia: evidence based on cerebrospinal fluid noradrenaline and cyclic nucleotide concentrations

UC Gomes, BC Shanley, L Potgieter and JT Roux

Concentrations of noradrenaline (NA), homovanillic acid, 5- hydroxyindoleacetic acid and cyclic nucleotides were determined in lumbar cerebrospinal fluid (CSF) from acute and chronic schizophrenics and various groups of psychiatric and non-psychiatric control subjects. Statistically significant increases in NA and cyclic adenosine monophosphate were found in CSF from chronic schizophrenics compared to all other groups. These results were shown by statistical analyses to be unrelated to medication. They may be interpreted as evidence for noradrenergic overactivity as a possible primary abnormality in chronic schizophrenia.


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Copyright © 1980 The Royal College of Psychiatrists.