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The British Journal of Psychiatry 137: 440-443 (1980)
© 1980 The Royal College of Psychiatrists

Viloxazine in the treatment of depressive neurosis: a controlled clinical study with doxepin and placebo

JP McEvoy, WF Sheridan, WR Stewart Jr, TA Ban, WH Wilson, W Guy and JD Schaffer

In a four-week, double-blind, clinical trial thirty-one patients with depressive neurosis were treated with viloxazine, doxepin, or placebo. There were no differences among the three groups in therapeutic effects. Many depressed out-patients improve on placebo. Viloxazine hydrochloride is one of a series of compounds developed to explore the central nervous system activity of the aryloxypropanolamine type of beta-adreno-receptor antagonists. Initial clinical study support the hypothesis that viloxazine has antidepressant properties in man (Bayliss et al, 1974; Bereen, 1973; Pichot et al., 1975; Tsegos and Ekdawi, 1974).




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1980 The Royal College of Psychiatrists.